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Screening for osteoporosis is primarily aimed at populations identified as being at higher risk for developing this condition, which is characterized by low bone density and increased fracture risk. The correct answer indicates that all 65-year-old women should be screened, as they are in a demographic that generally faces a higher risk of osteoporosis due to factors such as aging and hormonal changes associated with menopause.

Several guidelines recommend that women over the age of 65 undergo screening for osteoporosis because they are more susceptible to fractures and adverse health outcomes related to osteoporosis. Osteoporosis-related fractures can lead to significant morbidity and reduced quality of life, making early detection and management important.

In contrast, while all women aged 50 and over could benefit from consideration of risk factors, not all individuals in that category necessarily need immediate screening without further assessment of risk. Men, such as the 55-year-old with type 2 diabetes, do have elevated risk profiles, but general screening recommendations might not advocate for universal testing at that age for men unless additional risk factors are present. Additionally, screening for a healthier 45-year-old woman is generally unnecessary, as osteoporosis is rare in individuals this young unless there are specific risk factors involved, such as family history or other medical conditions.

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