Which SSRI is known for having a high potential for sedation and weight gain?

Paroxetine, commonly known as Paxil, is recognized for its potential to cause sedation and weight gain among the selective serotonin reuptake inhibitors (SSRIs). This medication affects serotonin levels in the brain, which can lead to both mood improvement and side effects. The sedative effect may be attributed to its additional antihistaminic activity, which can enhance drowsiness. Moreover, weight gain is a notable side effect linked to Paroxetine, potentially due to changes in metabolism and appetite regulation.

In comparison, other SSRIs such as Fluoxetine (Prozac) and Duloxetine (Cymbalta) are generally associated with a lower incidence of sedation and weight gain. Effexor, while not an SSRI but rather a serotonin-norepinephrine reuptake inhibitor (SNRI), also has different side effect profiles that do not typically emphasize sedation or significant weight gain. Understanding these differences in side effect profiles is important for healthcare providers when prescribing medications and counseling patients on what to expect during treatment.