Which side effect is related to autonomic dysfunction when using tricyclic antidepressants?

Autonomic dysfunction related to the use of tricyclic antidepressants can lead to orthostatic hypotension, which is a drop in blood pressure that occurs when a person stands up. This happens because tricyclic antidepressants can interfere with the body's ability to regulate blood pressure. By blocking certain neurotransmitters, these medications affect the autonomic nervous system, which is responsible for involuntary bodily functions including heart rate and blood pressure regulation. This disruption can cause dizziness, lightheadedness, and fainting, especially when transitioning from sitting or lying down to a standing position.

Understanding this side effect is crucial for healthcare providers and patients, as it necessitates careful monitoring of blood pressure and may require adjustments in dosage or consideration of alternative treatments if the side effect is significant. Other side effects listed, such as bradycardia (slowed heart rate), insomnia, and agitation, while possible with tricyclic antidepressants, do not specifically reflect autonomic dysfunction in the same way orthostatic hypotension does.