Which of the following side effects is associated with tricyclic antidepressants (TCAs)?

Tricyclic antidepressants (TCAs) are known to carry a risk of several side effects due to their mechanism of action, which primarily involves the inhibition of norepinephrine and serotonin reuptake, as well as their effects on various neurotransmitter receptors. One significant cardiovascular side effect that can occur with the use of TCAs is the prolongation of the QT interval on an electrocardiogram (EKG).

Prolonged QT interval is a serious condition that can lead to life-threatening arrhythmias, such as torsades de pointes. It arises because TCAs can block cardiac potassium channels, affecting the heart's electrical conduction system. Clinicians often monitor EKGs when patients are on these medications to prevent potentially severe complications.

In contrast, while individuals taking TCAs may experience an increase in appetite and possible weight gain, weight loss is not a typical side effect associated with these medications. Tremors are not a common side effect linked to TCAs either; instead, they are more frequently associated with other classes of drugs used for depression, such as selective serotonin reuptake inhibitors (SSRIs) or stimulants. Understanding these side effects helps particularly in monitoring and managing patients who may be at increased risk of cardiac issues while on