Which of the following is a clinical manifestation of Major Depressive Disorder?

Altered appetite is a key clinical manifestation of Major Depressive Disorder (MDD). Individuals may experience significant changes in their eating habits, which can manifest as either an increase or decrease in appetite. This symptom is often tied to the overall decline in mood and can lead to weight gain or loss, contributing to the disorder's impact on physical health.

In contrast, increased energy levels, heightened interest in activities, and improved social interactions are not characteristic of MDD. Typically, individuals with this disorder exhibit decreased energy, lack of interest in previously enjoyed activities (anhedonia), and often struggle with social interactions, resulting in feelings of isolation. Understanding these symptoms is crucial in identifying and diagnosing Major Depressive Disorder accurately.