Which neurotransmitter's deficiency is notably linked to Alzheimer's disease?

Acetylcholine is the neurotransmitter whose deficiency is notably linked to Alzheimer's disease. This connection is grounded in the role acetylcholine plays in memory and learning. In Alzheimer's disease, there is a progressive degeneration of neurons that produce acetylcholine, which leads to significant impairments in cognitive functions. The reduction of acetylcholine levels correlates with the severity of cognitive decline observed in patients with the disease.

Many treatment strategies for Alzheimer's focus on increasing acetylcholine levels to help alleviate symptoms and improve memory function. This underscores the importance of acetylcholine in maintaining cognitive health and highlights why its deficiency is particularly problematic in the context of Alzheimer's disease.