Which neurotransmitter is the major excitatory neurotransmitter involved in memory?

Glutamate is recognized as the major excitatory neurotransmitter that plays a crucial role in memory formation and cognitive functions. It is involved in synaptic plasticity, which is essential for learning and memory processes. When glutamate binds to its receptors in the brain, it promotes the activation of neurons, facilitating the transmission of signals between them. This excitatory action supports the strengthening of synapses, a key mechanism underlying the ability to learn and retain information.

While other neurotransmitters like serotonin, dopamine, and acetylcholine have significant roles in mood regulation, motivation, and various cognitive functions, they do not serve the primary role of promoting excitatory signaling in the context of memory as glutamate does.