Which medication is known to have a high risk of side effects like tardive dyskinesia and limited efficacy for negative symptoms of schizophrenia?

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Haloperidol is an antipsychotic medication that belongs to the class of first-generation, or typical, antipsychotics. One of the significant concerns with this class of medications is their association with movement disorders, particularly tardive dyskinesia, which is characterized by involuntary, repetitive body movements. This side effect arises from long-term use, as these medications block dopamine receptors in the brain.

Moreover, haloperidol is often less effective for treating the negative symptoms of schizophrenia, such as apathy, lack of emotion, or social withdrawal. Negative symptoms are generally more responsive to second-generation antipsychotics, which tend to have a different mechanism of action, allowing them to address both positive and negative symptoms more effectively. Therefore, haloperidol's profile of high side effect risk coupled with limited efficacy for negative symptoms makes it a fitting answer to the question posed.

The other options, while having their own efficacy and side effect profiles, do not match the combination of high risks for tardive dyskinesia and limited efficacy for negative symptoms as distinctly as haloperidol does.

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