Which medication can lead to an increased HIV viral load?

Efavirenz is an antiretroviral medication that is primarily used in the treatment of HIV. When patients are treated with efavirenz, it is essential that they adhere to the prescribed regimen. If efavirenz is not taken as directed or if there are interactions with other medications, it can sometimes lead to an increased HIV viral load. This increase occurs because efavirenz acts on the central nervous system and may cause issues like non-adherence due to side effects, which can lead to suboptimal drug levels in the body. Such scenarios may allow the virus to replicate more effectively, hence increasing the viral load.

In contrast, Atripla is a fixed-dose combination of efavirenz, tenofovir, and emtricitabine, and it integrates the functions of multiple components of HIV treatment, generally leading to viral suppression when taken correctly. Truvada, which contains tenofovir and emtricitabine, is also used in combination therapy essentially aimed at maintaining a low viral load. Darunavir is a protease inhibitor that also effectively reduces viral load when prescribed correctly and can be a part of a regimen to maintain viral suppression. These medications enhance overall efficacy in treatment and compliance, reducing the chances of an increased viral