Which mechanism of action does St. John's Wort utilize?

St. John's Wort primarily utilizes the mechanism of action that involves inhibiting the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine. This action increases the availability of these neurotransmitters in the synaptic cleft, enhancing mood and exerting antidepressant effects. Additionally, it has been suggested that St. John's Wort may also influence cortisol levels, although this effect is not as well established.

The mechanism enhances overall neurotransmitter activity, contributing to its efficacy in treating mild to moderate depression. By improving serotonin levels, St. John's Wort addresses symptoms associated with mood disorders, which aligns with its popularity as a natural remedy for depression and anxiety.

Other mechanisms of action, such as inducing neurotransmitter reuptake or blocking serotonin receptors, do not accurately describe how St. John's Wort functions. Rather than reducing neurotransmitter levels, it actively supports their availability, making it an effective option for those looking for non-traditional approaches to managing depression.