Which gender is most affected by Major Depressive Disorder (MDD)?

Major Depressive Disorder (MDD) shows a significant difference in prevalence rates between genders, with research indicating that females are affected at higher rates than males. This increased vulnerability in females is thought to be attributed to various factors, including hormonal fluctuations, social influences, and psychosocial stressors. Biological factors such as hormonal changes related to the menstrual cycle, pregnancy, and menopause may play a role, as well as cultural and societal expectations that can increase stress and impact mental health differently for women.

While males do experience MDD, the recognized patterns indicate that the disorder manifests differently in them, often leading to underdiagnosis or underreporting due to stigma surrounding mental health in men. Non-binary individuals may also experience mental health issues, but the data primarily highlights the prevalence among males and females, making it clear that females have a higher rate of diagnosis for MDD. Understanding these gender differences is crucial for developing appropriate therapeutic approaches and mental health interventions that effectively address the needs of those most impacted by Major Depressive Disorder.