Which diuretic is associated with hyponatremia when used concurrently with Sertraline?

Thiazide diuretics are known to be associated with hyponatremia, especially when used alongside medications like Sertraline, which is a selective serotonin reuptake inhibitor (SSRI). The mechanism behind this interaction lies in how thiazide diuretics affect sodium balance in the body.

Thiazide diuretics function primarily by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron. This leads not only to increased sodium excretion but may also promote fluid retention due to the diuretic's impact on electrolyte balance. When taken with an SSRI like Sertraline, there is an enhanced risk of hyponatremia because SSRIs themselves may contribute to the syndrome of inappropriate antidiuretic hormone secretion (SIADH), which compounds the effects of thiazides on sodium levels.

Osmotic, loop, and potassium-sparing diuretics do not share the same pronounced risk of causing hyponatremia when used in combination with Sertraline. Osmotic diuretics primarily exert effects through osmotic gradients and do not typically lead to significant sodium loss. Loop diuretics, while they can cause electrolyte imbalances, usually result in hypokalemia rather