Which condition is a contraindication for Bupropion (Wellbutrin)?

Bupropion, marketed under the name Wellbutrin, is an antidepressant that is also used for smoking cessation. It is classified as a norepinephrine-dopamine reuptake inhibitor (NDRI). One of the key safety considerations when prescribing bupropion is its potential to lower the seizure threshold, which is particularly concerning in patients with a history or risk factors for seizures.

In the case of anxiety or panic disorder, there is evidence suggesting that bupropion can exacerbate anxiety symptoms in some patients. This is particularly relevant for individuals who may be predisposed to seizures or heightened anxiety responses. Therefore, prescribing bupropion to a patient with an anxiety or panic disorder can lead to increased anxiety symptoms and greater associated risks, including the potential for seizures.

In contrast, chronic pain, post-traumatic stress disorder (PTSD), and attention deficit hyperactivity disorder (ADHD) are not absolute contraindications for bupropion. While caution may be warranted based on individual patient assessments, these conditions do not inherently pose the same risks associated with bupropion as anxiety or panic disorder does. Thus, the choice indicating anxiety or panic disorder as a contraindication for bupropion is supported by