Which clinical manifestation is typically associated with the abuse of psychostimulants like cocaine?

The clinical manifestation typically associated with the abuse of psychostimulants like cocaine is characterized by euphoria and agitation. When individuals consume stimulants, they experience a surge of energy and an elevated mood, often described as a euphoric state. This is due to the drug’s effects on the brain, particularly in increasing dopamine levels, which strongly influences feelings of pleasure and reward.

Agitation often accompanies this euphoric feeling as stimulants can also lead to heightened anxiety and restlessness. Users may exhibit increased physical activity, rapid speech, and an inability to remain still, which are common signs of agitation linked to stimulant use.

In contrast, the other clinical manifestations listed do not typically align with the immediate effects of psychostimulant use. Memory impairment might occur with long-term abuse or as a separate issue in substance use disorders, uninhibited sexual responses can be influenced by various factors but are not specific to stimulant abuse, and dry mouth and sedation are more commonly associated with depressants rather than stimulants. Thus, the viewpoint that euphoria and agitation are definitive responses reflects the core psychological and physical effects unique to psychostimulant use.