Which adverse effects are known to be associated with St. John's Wort?

St. John's Wort is a herbal supplement commonly used for its antidepressant effects, but it is also associated with a range of adverse effects. One of the most frequently reported side effects includes gastrointestinal upset, which can manifest as nausea, diarrhea, or dry mouth. Additionally, fatigue is another common issue that users may experience, likely due to the herb's influence on neurotransmitters and its interaction with various body systems.

While other side effects such as psychological effects, skin reactions, and physical effects can occur, the choice highlighting GI upset and fatigue comprehensively captures two of the more prevalent and documented side effects associated with St. John's Wort. By focusing on these specific reactions, the correct choice emphasizes the multifaceted impact that the herb can have on both the digestive system and overall energy levels.