What unique side effect can occur with Tricyclic Antidepressants (TCAs)?

The unique side effect associated with Tricyclic Antidepressants (TCAs) that is highlighted here is galactorrhea. This condition refers to the inappropriate flow of milk from the breast, which is not related to normal lactation. It can occur as a result of hormonal changes, particularly the elevation of prolactin levels, which may be influenced by the use of certain antidepressants, including TCAs.

While other side effects like weight gain, insomnia, and dry mouth are commonly associated with TCAs and many other classes of medications, galactorrhea is less frequently mentioned in connection to these drugs. It is important to recognize how medications can influence hormonal levels and cause reactions that might not be common, making galactorrhea a distinctive side effect worth noting when discussing TCAs.