What should be avoided when taking St. John's Wort due to drug interactions?

St. John's Wort is a herbal supplement commonly used for its antidepressant effects. However, it is known to interact with various prescription medications, particularly antiretrovirals and warfarin. The correct response highlights that these interactions can significantly diminish the effectiveness of these drugs or exacerbate side effects.

Antiretrovirals are used in the treatment of HIV/AIDS and can have their therapeutic effectiveness reduced when St. John's Wort is introduced, leading to possible treatment failure. Similarly, warfarin, which is an anticoagulant, can have its blood-thinning effects altered, potentially resulting in dangerous health outcomes like an increased risk of clotting or bleeding.

While other medications may also interact with St. John’s Wort, the most critical interactions are specifically with antiretrovirals and warfarin, making this the key choice to focus on. Other options suggest avoiding antidepressants, all prescription medications, or over-the-counter pain relievers, but the most notable and clinically significant interactions primarily involve those two categories.