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Trepanation refers to an ancient medical practice that involves drilling or scraping a hole into the human skull. This procedure was historically thought to treat various conditions, such as head injuries, migraines, and mental health disorders, by allowing evil spirits to escape or by relieving pressure in the skull. Evidence of trepanation dates back thousands of years, with archaeological findings showing skulls with trepanation holes from prehistoric times.

The historical context and usage of trepanation set it apart from the other choices, which do not accurately describe what trepanation is. Modern surgical practices have evolved significantly and are usually safer and more effective than ancient methods like trepanation. Psychological assessment tools and therapeutic techniques do not involve any physical alteration of the skull, which is critical to understanding the specific nature of trepanation. Therefore, recognizing trepanation as an ancient practice of drilling holes in the skull is fundamental to its definition and historical significance.

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