What is the mechanism of action (MOA) for SNRIs?

The mechanism of action for serotonin-norepinephrine reuptake inhibitors (SNRIs) involves the blockage of the reuptake of two key neurotransmitters: serotonin and norepinephrine. By inhibiting the reabsorption of these neurotransmitters back into the presynaptic neuron, SNRIs increase their availability in the synaptic cleft. This enhanced level of serotonin and norepinephrine contributes to improved mood and alleviates symptoms associated with depression and anxiety disorders.

The interaction of SNRIs with these neurotransmitters is significant because serotonin is primarily linked to mood regulation, while norepinephrine is associated with arousal and alertness. The combined effect of elevating both neurotransmitters allows SNRIs to be effective in treating various mental health conditions.

In contrast, other mechanisms mentioned in the options do not accurately describe the action of SNRIs. For instance, inhibiting monoamine oxidase pertains to a different class of antidepressants known as monoamine oxidase inhibitors (MAOIs), while increasing dopamine levels is primarily related to other medications, such as certain stimulants. Stabilizing mood swings is more associated with mood stabilizers rather than SNRIs specifically. Therefore, the correct understanding of the mechanism of