What is a potential risk of combining alcohol with Duloxetine (Cymbalta)?

Combining alcohol with Duloxetine, commonly known as Cymbalta, poses a potential risk of hepatotoxicity, which refers to liver damage. Duloxetine is metabolized by the liver, and the presence of alcohol can increase the liver's workload, leading to elevated liver enzyme levels and potentially serious liver injury. This risk is particularly significant for individuals with pre-existing liver conditions or those who consume alcohol heavily.

The other choices are less relevant in this context. Increased anxiety is not a recognized primary effect of this combination; while alcohol can cause mood fluctuations, the specific interaction with Duloxetine generally concerns liver health. Rapid weight gain is not directly linked to the combination, though weight changes can occur with Duloxetine alone. Decreased anxiety may occur as an intended effect of Duloxetine; however, alcohol consumption can actually exacerbate symptoms of anxiety over time, counteracting the medication's therapeutic effects. Therefore, understanding the risk of hepatotoxicity highlights the importance of avoiding alcohol while taking Duloxetine.