What is a notable side effect of Lamotrigine (Lamictal) in the treatment of bipolar disorder?

Lamotrigine (Lamictal) is used to stabilize mood in individuals with bipolar disorder, and one of the notable side effects associated with this medication is the potential development of a severe rash, which can progress to Stevens-Johnson Syndrome (SJS). This condition is a serious and potentially life-threatening skin reaction characterized by widespread skin detachment and ulceration. It can be triggered by various medications, including Lamotrigine, particularly if the dosage is escalated too quickly.

The risk of SJS is particularly significant when the drug is introduced or its dose increased, highlighting the importance of healthcare providers monitoring patients closely during these periods. This knowledge is crucial for both patients and healthcare professionals to mitigate risks effectively.

While other medications can have their own side effects, weight gain, kidney damage, and pancreatitis are not prominently associated with Lamotrigine in the context of bipolar disorder treatment, making the severe rash linked with SJS the key concern for this medication.