What is a contraindication to prescribing bupropion for smoking cessation?

Bupropion is an atypical antidepressant that is also used to help individuals quit smoking. However, it has certain contraindications that make it unsuitable for some patients. One of the primary contraindications is a seizure disorder. This is because bupropion can lower the seizure threshold, meaning it increases the likelihood of seizures occurring. Patients with a history of seizures or conditions that predispose them to seizures should not be prescribed bupropion, as this could lead to serious complications.

In contrast, while chronic obstructive pulmonary disease (COPD), depression, and cardiovascular disease may complicate treatment or require careful monitoring, they do not directly contraindicate the use of bupropion itself. Patients with COPD may require modifications in their smoking cessation strategy, but bupropion can still be considered under a healthcare provider's guidance. Depression can actually be treated with bupropion, and for patients with cardiovascular disease, bupropion has shown to be relatively safe when monitored properly. Therefore, among the options provided, a seizure disorder is the clear contraindication for prescribing bupropion.