What is a common adverse effect associated with SAMe?

Insomnia is a common adverse effect associated with SAMe (S-adenosylmethionine), which is often used as a supplement for mood improvement and treating conditions such as depression. SAMe is known to influence neurotransmitter activity in the brain, particularly those related to mood and sleep. As a result, some individuals may experience disturbances in their sleep patterns, leading to insomnia.

The other options listed, while potentially relevant to various medications or supplements, are not typically linked with SAMe in the same way. Rash is generally associated with allergic reactions or skin sensitivities, while weight gain is not commonly reported as a direct effect of SAMe. Drowsiness, although it may occur in some individuals, is less frequently highlighted in relation to SAMe, especially since it is often sought for its mood-stabilizing effects that do not typically lead to sedation or excessive sleepiness. Understanding these nuances can help in identifying how SAMe may impact individuals differently based on their unique responses to the supplement.