What is a common adverse effect of St. John's Wort?

St. John's Wort, a popular herbal remedy primarily used for depression and anxiety, is known to have several potential adverse effects, with gastrointestinal upset being one of the more common ones. GI upset can manifest as nausea, diarrhea, or general stomach discomfort and is often linked to the active compounds within St. John's Wort that affect serotonin levels in the gut.

The reason GI upset is particularly relevant is that the gastrointestinal system is sensitive to changes in neurotransmitter levels. Other factors like the dosage of the supplement, individual sensitivity, and specific interactions with other medications can further increase the likelihood of experiencing these gastrointestinal issues.

In contrast, increased appetite, weight gain, and blurred vision are not commonly associated with St. John's Wort. While some medications might cause changes in appetite or weight, St. John's Wort is more frequently noted for potential stimulation rather than appetite increase. Similarly, blurred vision is not a well-documented side effect related to this herbal remedy. Therefore, GI upset stands out as a significant concern when considering the adverse effects of St. John’s Wort.