What does "tolerance" mean in the context of drug use?

In the context of drug use, "tolerance" refers to the body's adaptation to a substance, which results in the need for larger amounts of the drug to achieve the desired effect. As an individual continues to use a drug, their body becomes accustomed to its presence, often diminishing the initial effects that were experienced at lower doses. This process can lead to an increase in the quantity of the drug consumed, as the same dose becomes less effective over time.

Understanding tolerance is crucial, especially in the context of addiction and substance dependence. People who develop tolerance may find themselves gradually increasing their dosage, which can heighten the risk of overdose and other health complications. This concept underscores the importance of monitoring substance use and recognizing changes in one's response to drugs.