What class of medications do Clonidine and Guanfacine belong to in the treatment of ADHD?

Clonidine and Guanfacine are categorized as non-stimulant medications used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). These medications are primarily alpha-2 adrenergic agonists that help regulate attention and impulse control by affecting the norepinephrine pathways in the brain.

Unlike stimulant medications, which are the first-line treatment for ADHD and work by increasing the levels of dopamine and norepinephrine, non-stimulants like Clonidine and Guanfacine offer an alternative for patients who may not tolerate stimulants well or for whom stimulants are contraindicated. Non-stimulants can also be beneficial in treating ADHD symptoms in patients who may have coexisting conditions, such as anxiety or aggression, because they tend to have a more gradual onset of action and a different side effect profile.

In summary, classifying Clonidine and Guanfacine as non-stimulants accurately reflects their mechanism of action and therapeutic role in managing ADHD symptoms.