In which situation is Bupropion (Wellbutrin) particularly contraindicated?

Bupropion, commonly branded as Wellbutrin, is an antidepressant that is particularly contraindicated in patients with a history of seizures. This is due to Bupropion's potential to lower the seizure threshold, thereby increasing the risk of seizures in individuals who have a pre-existing susceptibility. The medication can lead to increased excitability in the central nervous system, making it unsuitable for those who have had any history of seizure disorders.

In contrast, while chronic fatigue, a balanced diet, and mild stress may be relevant in clinical considerations, they do not pose the same direct risk as a history of seizures when it comes to prescribing Bupropion. The contraindication stems from the drug’s pharmacological effects and the need to prioritize patient safety in those known to have seizure disorders.