How long does it typically take for St. John's Wort to show full therapeutic effects?

St. John's Wort, a popular herbal remedy often used for mild to moderate depression, typically shows its full therapeutic effects after a duration of about 2 months. This time frame is attributed to the gradual way in which the active compounds in St. John's Wort, such as hypericin and hyperforin, need to accumulate in the body and exert their influence on neurotransmitter systems. It is essential to understand that many herbal supplements, including St. John's Wort, may not provide immediate relief, and consistent use over several weeks is often necessary to assess their efficacy fully. This gradual onset of action is crucial for setting realistic expectations for individuals considering this treatment for mood-related issues.