For a woman experiencing postpartum depression, which medication is most appropriate to prescribe?

Sertraline is considered the most appropriate medication for a woman experiencing postpartum depression, primarily because it is a selective serotonin reuptake inhibitor (SSRI) that is commonly used to treat depression and anxiety disorders. SSRIs are generally preferred for their efficacy and safety profile, particularly in women who are postpartum, as they have a lower risk of adverse effects compared to other classes of antidepressants.

One significant factor in choosing sertraline for postpartum depression is its relative safety for breastfeeding mothers. Research indicates that sertraline has been studied in relation to breast milk and has shown to have minimal transfer to the infant, making it a more suitable choice for new mothers concerned about medication effects on their child.

The other medications listed do not align with the recommended treatment protocols for postpartum depression. Amitriptyline, while used for depression, is a tricyclic antidepressant that can have a higher side effect profile and is not typically the first line for postpartum cases. Diazepam is a benzodiazepine primarily used for anxiety and is not indicated for depression, as it can lead to dependence and sedation, which may not be safe for a new mother. Phenytoin is an antiepileptic medication and is irrelevant in the context of treating depression.